Sulfobutyl Ether-beta-cyclodextrin Sodium Salt

DMF No.: 030167

Name: Sulfobutyl ether-beta-cyclodextrin sodium salt  

Other name : Betadex sulfobutyl ether sodium ; Sulfobutyl ether-β-cyclodextrin sodium salt 

CAS No.: 182410-00-0

Abbreviation: SBEBCD

Molecular formula : C₄₂H_70-nO₃₅ (C₄H₈O₃S Na)n 

Molecular weight: 1135+158n

Qaulity:Injection grade

Standard : USP40

Package: 500g/bag , 1kg/bag , 2kg/bag, 10kg/drum , 20kg/drum or customized

Use:medical 

Specification : USP40

Standard	USP40-NF35
ITEMS	SPECIFICATION
Appearance	White to off-white solid, free from foreign matter
Solution Clarity	A 30%w/v solution in water is clear and essentially free from particles of foreign matter
Identification (IR)	Consistent with SBECD standard
Identification(Sodium)	Identify test are positive for Sodium
Identification（LC）	the retention time of the major peak of  sample solution corresponds to the  standard solution
Average Degree of Substitution	6.2-6.9
Water solution pH	pH of 30%w/v solution in water is 4.0-6.8
Heavy Metals	≤5ppm
Water	≤10%
β-Cyclodextrin Content	≤0.1%
Sodium Chloride	≤0.2%
1,4-butane sultone	≤0.5ppm
4-Hydroxybutane-1-Sulfonic Acid	≤0.09%
Disodium bis-(4-sulfobtyl) ether	≤0.05%
Assay	95%-105%
Bacterial endotoxins	≤20EU/g
Microbiology
Total viable aerobic count (mould plus yeast)	≤100CFU/g
Escherichia Coli	Absence
mould plus yeast	≤50CFU/g

Features and applications:

Sulfobutyl ether-beta-cyclodextrin sodium salt  is a high water-soluble anionic cyclodextrin derivative. It can easily form non-covalent inclusion complexes with drug molecules, thus it has the good performances in enhancing drug stability, solubility and safety, reducing drug toxicity and hemolysis, covering up bad smell, and controlling drug release rate.

Sulfobutyl ether-beta-cyclodextrin sodium salt has been used in injection, oral, nasal and eye medication. Modification by charged functional units can improve the binding affinity of cyclodextrins for oppositely charged guests, so it has a special affinity for drugs with nitrogen elements.

Product performance
1, Solubility:
Neutral, positive and negative APIs can be effectively combined with betadex sulfobutyl ether sodium to increase the solubility of the compound by 10 to 25,000 times.
2, Facilitate the drug
Betadex sulfobutyl ether sodium has a good biocompatibility and can be administered by injection, oral, ocular, nasal, topical and inhalation.
3, Good security
In general, it can be quickly and completely removed from the kidneys after administration. In vitro experiments and in vivo acute, subacute and chronic toxicity studies provide safe data and approval for use with pharmaceutical preparations.
4, Good stability
The interaction with sulfobutyricotriacodextrin provides a beneficial protective environment for the drug substance in its lipophilic chamber, while the hydrophilic surface provides excellent water solubility to provide solubility and stability.

If you're looking for the high-quality sulfobutyl ether-beta-cyclodextrin sodium salt, our company will be your best choice. We're one of the leading manufacturers and supplier with rich experience and wide expertise. Please be rest assured to buy the products from our factory.

If you're looking for the high-quality sulfobutyl ether-beta-cyclodextrin sodium salt, our company must be your best choice. We're one of the leading manufacturers and supplier with rich experience and wide expertise. Please be rest assured to buy the products from our factory.