Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Tel: +86-543-2616568

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    Add: Boxing Economic Development Zone, Binzhou, Shandong, China

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Hydroxypropyl Beta-cyclodextrin In The Treatment Of Glaucoma

Hydroxypropyl beta-cyclodextrin in the treatment of glaucoma

The frequent elevation of intraocular pressure in glaucoma patients leads to the gradual injury of optic nerve, so it is necessary to take a large amount of acetazolamide to effectively reduce intraocular pressure, but taking this drug often produces systemic side effects. Acetazolamide is a hydrophobic non-ionic drug with a solubility of 6.7 mg / ml in aqueous solution. And the drug is not easy to pass through such biofilm as cornea, so it can not make effective acetazolamide water-soluble eye drops.

Hydroxypropyl beta-cyclodextrin was used in acetazolamide aqueous solution to prepare 1% water-soluble acetazolamide eye drops. The effects of the eye drops were evaluated by animal and human experiments. The patients were given eye drops three times a day. The intraocular pressure decreased by 15.5% ±8.9% after 28 days. After 7th days of administration, the maximum reduction was 17.4% ±12.7. the effect of acetazolamide eye drops on intraocular pressure was similar to that of 2% dozolamide hydrochloride eye drops sold on the market. At first, acetazolamide as a carbonic anhydrase inhibitor was not suitable for eye administration to reduce intraocular pressure. Acetazolamide eye drops with hydroxypropyl beta-cyclodextrin had good ocular tolerance.

The introduction of cyclodextrin expands the drug use channels, reduces the risk of drug use, and brings good news to patients.

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd is a high-tech enterprise specialized in producing cyclodextrin derivatives.

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