Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
Tel: +86-543-2616568
Fax: +86-543-2605568
Email: info@cydextrin.com
Add: Boxing Economic Development Zone, Binzhou, Shandong, China
Conditions for condensation of β-cyclodextrin with propylene oxide were found
which give preparations of hydroxypropyl-β-cyclodextrin with a narrow
and symmetrical distribution of the degree of substitution. Furthermore,
methods for purification of hydroxypropyl-β-cyclodextrins from the
contaminating oligopropylene glycols were developed. Preparations
of hydroxypropyl-β-cyclodextrin with low degrees of substitution
( < 8) were found to have optimal solubilization properties for drugs and also
these preparations could be transformed into non-hygroscopic powders;
the preparations with higher degrees of substitution (12–14) were semi-solids of lower solubilization power. The solubilities of 32 drugs in concentrated
aqueous solutions of hydroxypropyl-β-cyclo-dextrins (40–50%) were measured;
some of these were improved by three orders of magnitude over the corresponding
solubilities in water.