Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Tel: +86-543-2616568

    Fax: +86-543-2605568

    Email: info@cydextrin.com

    Add: Boxing Economic Development Zone, Binzhou, Shandong, China

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Dimethyl-β-cyclodextrin Can Be Used To Prepare Nasal Spray Of Carfentanil

Carfentanil (CFTN) is a derivative of fentanyl with significant analgesic effect but poor water solubility. The dimethyl-β-cyclodextrin (DM-β-CD) inclusion complex containing CFTN and its nasal spray were prepared by ultrasonic method, which can increase the solubility of CFTN. The dissolution rate of the inclusion complex in hydrochloric acid and phosphate buffer was significantly higher than that of free CFTN. Rats were used as a model for in vivo testing, and CFTN-DM-β-CD clathrate (250 μg/kg) was administered intravenously, intramuscularly, orally and intranasally. Results Compared with intramuscular and oral administration, CFTN-DM-β-CD inclusion compound absorbed faster, cmax and bioavailability by nasal administration. Therefore, the CFTN-DM-β-CD inclusion compound nasal spray is a relatively safe, fast acting and effective dosage form.

Dimethyl-β-cyclodextrin can be used to prepare nasal spray of carfentanil.jpg

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Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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