Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Tel: +86-543-2616568

    Fax: +86-543-2605568

    Email: info@cydextrin.com

    Add: Boxing Economic Development Zone, Binzhou, Shandong, China

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Application Of Cyclodextrin In Inclusion Compound

The void of the cyclodextrin is composed of a carbon-hydrogen bond and an ether bond as a hydrophobic region.

The non-polar fat-soluble molecules interact with the hydrophobic bonds in the main molecular cavity to form an inclusion complex, but the solubility is small.The polar molecule forms a hydrogen bond with the hydroxyl group of the cyclodextrin molecule, and is located at the opening of the hole, and the formed inclusion compound has a large water solubility.Hydrophobic guest molecules are easily encapsulated, and non-dissociated molecules are more easily encapsulated than dissociated guest molecules.

Solubilization studies of cyclodextrin inclusion complexes have spread throughout almost all poorly soluble compounds.

Hydroxypropyl betadexis readily soluble in water by cyclodextrin and has a solubility of 750 g/L.The low-substituted HP-β-CD is an ideal solubilizing agent for poorly soluble drugs, and has low hemolytic activity. The freeze-dried powder can be directly compressed, and these tablets are kept at room temperature for several months, and the appearance is unchanged.

Application of cyclodextrin in inclusion compound

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 E-mail:info@cydextrin.com
Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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