Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

    Tel: +86-543-2616568

    Fax: +86-543-2605568

    Email: info@cydextrin.com

    Add: Boxing Economic Development Zone, Binzhou, Shandong, China

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Breviscapine is better coated with hydroxypropyl beta cyclodextrin

Breviscapine has the effect of dilating cerebral blood vessels, reducing cerebral vascular resistance, increasing cerebral blood flow, improving microcirculation, and countering platelet aggregation. Breviscapine is a water-insoluble, oil-insoluble weakly acidic drug, which has a small solubility in an organic solvent, dissolves in an acidic solution, and has a low oil/water partition coefficient. Studies have shown that breviscapine is absorbed quickly in the body after intravenous administration, has a short half-life, is rapidly eliminated, and has a short effective concentration. Oral tablets have low bioavailability and are hardly absorbed, requiring multiple doses of multiple doses to achieve therapeutic goals.

Hydroxypropyl beta cyclodextrin is hydrophobic inside the tubular structure, so hydrophobic guest molecules are easily encapsulated to form clathrates. Studies have shown that the use of hydroxypropyl beta cyclodextrin to encapsulate breviscapine into a new dosage form, effectively overcome the double shortcomings of breviscapine injection, such as short half-life, rapid elimination in vivo, and low bioavailability of oral administration. It can also ensure the therapeutic effect of breviscapine and make it convenient for patients to use.

Breviscapine is better coated with hydroxypropyl beta cyclodextrin

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Address: Boxing Economic Development Zone, Binzhou, Shandong, China
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E-mail:info@cydextrin.com
Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd
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