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    Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd

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Hydroxypropyl Betadex 128446-35-5

Hydroxypropyl Betadex 128446-35-5

Application of HPBCD in eye drops.

Basic information

Name: Hydroxypropyl betadex

CAS: 128446-35-5

Molecular formula :C42H70-nO35(C3H8O2)n

Molecular weight: 1134.98+58n

Qaulity : Pharma grade / food grade / cosmetics grade / industry grade

Standard : USP39/ EP9.0

Package: 500g/bag , 1kg/bag,  10kg/drum , 20kg/drum or customized


The role in ophthalmic medicine

Hydroxypropyl betadex can improve the solubility, stability and corneal permeability of the drug in the ophthalmological agents. Puerarin has the beta receptor blocking effect, can reduce the intraocular pressure, and can improve the fundus microcirculation, by phase solubility method and in vitro corneal diffusion experiment of hydroxypropyl betadex on Puerarin solubility and rabbit corneal permeability effect, the results show that the use of hydroxypropyl betadex on solubilization of puerarin and it can achieve good effect, and can improve the permeability of drugs and no irritation of the cornea. Chloramphenicol Eye Drops is sensitive to the treatment of bacterial conjunctivitis, keratitis, ocular infection of chlamydia as the drug of choice, but chloramphenicol has high sensitivity to temperature, temperature rise caused by hydrolysis of chloramphenicol and glycols, resulting in the decreased, reduce the drug effect. To compare the bacteriostatic effect of chloramphenicol hydroxypropyl betadex eye drops, chloramphenicol Sodium Hyaluronate Eye Drops and Chloramphenicol Eye Drops on Staphylococcus aureus and Escherichia coli. hydroxypropyl betadex enhanced the stability of Chloramphenicol Eye Drops and had no obvious effect on its bacteriostasis.



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